Author

Kyra Raines

Broad InstituteORCID 0000-0003-4930-6038Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Deborah Tan HungiD· 2 shared Josephine BagnalliD· 2 shared Keith P. RomanoiD· 2 shared Kristina M. FerraraiD· 2 shared Noam Shoresh FiD· 2 shared Thulasi WarrieriD· 2 shared Aaron J. GolasiD· 1 shared Andras BoeszoermenyiiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersMicrobiology

Deborah Tan HungORCID

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2 papers

Recent·Most cited

MicrobiologyCell chemical biologyPeer-reviewedDec 27, 2024

Multiplexed screen identifies a Pseudomonas aeruginosa-specific small molecule targeting the outer membrane protein OprH and its interaction with LPS

Bradley E. Poulsen, Thulasi Warrier, Sulyman Barkho…·Deborah Tan Hung

The paper identifies a Pseudomonas aeruginosa-specific small molecule, BRD1401, that targets OprH and disrupts its interaction with LPS, increasing membrane fluidity.

11 citations

bacteria (other)experimental assay

𝕏 PostBluesky

GenomicsProceedings of the National Academy of SciencesPeer-reviewedOct 28, 2024

Perturbation-Specific Transcriptional Mapping for unbiased target elucidation of antibiotics.

Keith P. Romano, Josephine Bagnall, Thulasi Warrier…·Deborah Tan Hung

This paper introduces PerSpecTM, a method to predict antibiotic mechanisms of action by comparing transcriptional responses of new molecules to known perturbations, demonstrating its effectiveness with three new anti-Pseudomonas aeruginosa compounds.

9 citations

bacteria (other)bulk RNA-seq

𝕏 PostBluesky