Author

Marvel Tranquille

Weill Cornell MedicineORCID 0000-0002-6608-5778Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Abigail S. KingiD· 2 shared Allyson J. OceaniD· 2 shared Andrea SboneriD· 2 shared Cora Nanette SternbergiD· 2 shared Daniela E. GuevaraiD· 2 shared David C. WilkesiD· 2 shared David M. NanusiD· 2 shared Eloise Chapman‐DavisiD· 2 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Abigail S. KingORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 10, 2025

Pan-Cancer PDOs Preserve Tumor Heterogeneity and Uncover Therapeutic Vulnerabilities

Hui–Hsuan Kuo, Bhavneet Bhinder, Hamza Numan Gokozan…·M. Laura Martín

This study develops a pan-cancer PDO platform to preserve tumor heterogeneity and identify therapeutic vulnerabilities, finding that 58% of PDOs respond to Talazoparib and combination screens reveal resistance-overcoming drugs.

DOI 10.1101/2025.04.10.647635

humanbulk RNA-seq

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Genetic & Genomic MedicinemedRxivPreprintJun 28, 2024

Whole Genome Landscape Analysis of Homologous Recombination Deficiency in a Pan-Cancer Cohort

Majd Al Assaad, Kevin Hadi, Max Fine Levine…·Juan Miguel Mosquera

The paper analyzes whole-genome sequencing data from a pan-cancer cohort to define HRD, showing it extends beyond BRCA1/2 mutations and highlights the benefits of WGS over commercial assays for HRD detection.

3 citations

humanwhole-genome sequencing

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NeurosciencePLoS GeneticsPeer-reviewedNov 1, 2021

A behavioral screen for mediators of age-dependent TDP-43 neurodegeneration identifies SF2/SRSF1 among a group of potent suppressors in both neurons and glia.

Jorge Azpurua, Enas A. Elkarim, Marvel Tranquille, Josh Dubnau

The paper identifies SF2/SRSF1 as a suppressor of TDP-43 toxicity in both neurons and glia through a Drosophila behavioral screen.

17 citations

Drosophilaexperimental assay

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