Author

Simseok A. Yuk

Northwestern UniversityORCID 0000-0002-6610-4940Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Assay:multiome· 1

Frequent Co-Authors

Evan Alexander ScottiD· 3 shared Sultan AlmunifiD· 3 shared Swagat SharmaiD· 2 shared Boaz Bishop· 1 shared C. Ramsey GraceiD· 1 shared Clive Henry WasserfalliD· 1 shared Débora B. ScariotiD· 1 shared Drew H. LandrowskiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBioengineering

Evan Alexander ScottORCID

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3 papers

Recent·Most cited

Nanotherapy-mediated biased antigen-presenting cell reprogramming supports T cell anergy to prevent type 1 diabetes

N. Klug, El Hadji Arona Mbaye, SZUMO WANG, Sultan Almunif, C. Ramsey Grace, Joseph W. Reda, Débora B. Scariot, Simseok A. Yuk, Yu-Gang Liu, Drew H. Landrowski, Swagat Sharma, Haeik Park, Jeffrey A. Hubbell, Clive Henry Wasserfall, Evan Alexander Scott, Jacqueline A. Burke

This paper develops a nanotherapy to reprogram antigen-presenting cells and induce T cell anergy, delaying type 1 diabetes onset in mice.

bioRxiv · Oct 23, 2026 · PreprintBioengineering

Expression of a RAS degrader via synthetic nanocarrier-mediated mRNA delivery reduces pancreatic tumors

Taylor E. Escher, Simseok A. Yuk, Qian Yuan, Wenan Qiang, Sultan Almunif, Swagat Sharma, Evan Alexander Scott, K.J.F. Satchell

The paper demonstrates that synthetic nanocarriers deliver RAS-degrading mRNA to pancreatic tumors, reducing RAS levels and tumor growth.

ACS Applied Bio Materials · May 29, 2025Peer-reviewedCancer Biology

Enabling Organ- and Injury-Specific Nanocarrier Targeting via Surface-Functionalized PEG-b-PPS Micelles for Acute Kidney Injury

Boaz Bishop, Swagat H. Sharma, Ratnakar Tiwari, Simseok A. Yuk, Sultan Almunif, Susan E. Quaggin, Evan Alexander Scott, Pinelopi P. Kapitsinou

This paper develops dual-ligand micelles for targeted nanocarrier delivery in acute kidney injury, showing enhanced accumulation in injured kidneys and reduced off-target distribution.

Nanoscale Horizons · Jan 1, 2025Peer-reviewedBioengineering