Author

Cheng-Fu Kao

Institute of Cellular and Organismic Biology, Academia SinicaORCID 0000-0002-8875-8152Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 4 Biochemistry· 1 Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Approach:statistical model· 4 Organism:yeast· 4 Assay:bulk RNA-seq· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Assay:ChIP-seq· 2 Research Focus:differential expression· 2

Frequent Co-Authors

Chia-Ling HsuiD· 3 shared Chia‐Yeh Lin· 2 shared Hsin-Yi Tseng· 2 shared Amy LarsoniD· 1 shared Chien‐Chang CheniD· 1 shared Ching-Chih WuiD· 1 shared Chu-Yuan Chang· 1 shared Chung-Shu YehiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersMolecular Biology

Chia-Ling HsuORCID

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7 papers

Recent·Most cited

Transcription-Coupled Chromatin Reinforcement Maintains the Mature Cardiomyocyte State

H F Tang, Hsin-Yi Tseng, Chia‐Yeh Lin, Cheng-Fu Kao

This study shows that RNF20 maintains chromatin accessibility in adult cardiomyocytes, preventing stress-responsive enhancer activation and preserving cell state integrity.

bioRxiv · Sep 8, 2026 · PreprintGenetics

Rpd3L Coordinates Chromatin State and Transcription-Replication Conflict Resolution through H3K4 Methylation-Dependent and Independent Mechanisms

Shin Yen Chong, Yaling Chen, Yueh-Tzu Hsu, Chia-Ling Hsu, Tsai-Ming Lu, Yi‐Chen Lo, Cheng-Fu Kao

This study shows Rpd3L modulates chromatin state and resolves transcription-replication conflicts in yeast through H3K4 methylation-dependent and independent mechanisms, preventing genome instability.

bioRxiv · Apr 15, 2026 · PreprintMolecular Biology

A topologically conserved unstructured region helps positioning the evolutionarily conserved Prp40 WW domains to promote non-canonical intron splicing

Luh Tung, Chung-Shu Yeh, Hsin-Hung Lin, Hsin‐Yue Tsai, Shang‐Lin Chang, Amy Larson, Hsuan-Kai Wang, Fu-Lung Yeh, Chia-Ling Hsu, Cheng-Fu Kao, Jeffrey A. Pleiss, Wei‐Hau Chang, Tien‐Hsien Chang

This paper identifies a conserved unstructured region in Prp40 WW domains that facilitates their positioning to promote non-canonical intron splicing in yeast.

bioRxiv · Oct 29, 2025 · PreprintBiochemistry

Chromatin state transition underlies the temporal changes in gene expression during cardiomyocyte maturation

Chia‐Yeh Lin, Yao‐Ming Chang, Hsin-Yi Tseng, Yen-Ling Shih, Hsiao-Hui Yeh, You-Rou Liao, Han-Hsuan Tang, Chia-Ling Hsu, Chien‐Chang Chen, Yu‐Ting Yan, Cheng-Fu Kao

This study identifies RNF20-mediated chromatin state transitions as critical for time-ordered gene expression during cardiomyocyte maturation and links its disruption to congenital heart disease.

Cell Reports · Nov 1, 2023Peer-reviewedDevelopmental Biology

Chromatin Fiber Folding Represses Transcription and Loop Extrusion in Quiescent Cells

Sarah G. Swygert, Dejun Lin, Stephanie Portillo‐Ledesma, Po-Yen Lin, Dakota R. Hunt, Cheng-Fu Kao, Tamar Schlick A, William Stafford Noble, Toshio Tsukiyama

The paper shows that chromatin fiber folding in quiescent yeast represses transcription and loop extrusion, with H4 tail modifications affecting fiber structure and function.

eLife · Nov 4, 2021Peer-reviewedMolecular Biology

Enhancer regulation for induced WNT3A expression during neuronal regeneration

Chu-Yuan Chang, Jui‐Hung Hung, Ching-Chih Wu, Min-Zong Liang, Pei-Yuan Huang, Joye Li, Hong‐I Chen, Shaw‐Fang Yet, Ka Shing Fung, Cheng-Fu Kao, Linyi Chen

This study investigates how WNT3A expression is regulated during neuronal regeneration after traumatic brain injury by analyzing epigenetic changes in enhancers.

bioRxiv · Dec 2, 2019 · PreprintMolecular Biology

Experimental evolution reveals a general role for the methyltransferase Hmt1 in noise buffering

Shu‐Ting You, Yu‐Ting Jhou, Cheng-Fu Kao, Jun‐Yi Leu

The paper uses experimental evolution in yeast to identify Hmt1 as a general regulator of noise buffering, showing its role in adjusting noise levels in response to environmental cues and its conservation across species.

PLoS Biology · Oct 15, 2019Peer-reviewedMolecular Biology