This study identifies METTL7A as a mechanosensitive methyltransferase that regulates internal m7G methylation in endothelial cells, protecting against atherosclerosis through stabilization of anti-inflammatory transcripts.

Circulation · Aug 11, 2026Peer-reviewedMolecular Biology

Precision mRNA Nanomedicine for Targeted Vascular Therapies in ARDS and Atherosclerosis

Zhengjie Zhou, Jiayu Zhu, Chih‐Fan Yeh, Angelo Y. Meliton, David Wu, Ru‐Ting Huang, Tzu‐Pin Shentu, Aleepta Guha Ray, Destini Wiseman, Erica Budina, Aaron T. Alpar, Kai‐Chien Yang, Jeffrey A. Hubbell, Ada Weinstock, Gökhan M. Mutlu, , Yun Hua Fang

This paper develops a modular nanoparticle platform for targeted mRNA delivery to inflamed endothelial cells, showing efficacy in treating ARDS and atherosclerosis by restoring disease-related gene pathways.

bioRxiv · Jan 9, 2025 · PreprintBioengineering

Comparative single-cell profiling reveals distinct cardiac resident macrophages essential for zebrafish heart regeneration

Ke-Hsuan Wei, I-Ting Lin, Kaushik Chowdhury, Khai Lone Lim, Kuan‐Ting Liu, Tai‐Ming Ko, Yao‐Ming Chang, Kai‐Chien Yang, Shih-Lei Lai

The paper identifies distinct cardiac resident macrophage subpopulations critical for zebrafish heart regeneration through comparative single-cell profiling.

eLife · Jul 27, 2023Peer-reviewedDevelopmental Biology