Shih-Lei Lai

IFN-γ-Dependent Macrophage Reprogramming Coordinates Inflammatory Resolution and Matrix Remodeling in Heart Regeneration

This study identifies IFN-γ as critical for macrophage reprogramming during zebrafish heart regeneration, linking inflammatory resolution to ECM remodeling.

Scube2 Modulates Coronary Vessel Formation during Cardiac Growth and Regeneration in Zebrafish

This study identifies Scube2 as a regulator of coronary vessel formation and heart regeneration in zebrafish, showing its role in vascular coverage, myocardial structure, and revascularization after injury.

Border-zone cardiomyocytes and macrophages contribute to remodeling of the extracellular matrix to promote cardiomyocyte invasion during zebrafish cardiac regeneration

This study identifies border-zone cardiomyocytes and macrophages as key contributors to ECM remodeling that facilitates cardiomyocyte invasion during zebrafish cardiac regeneration.

Comparative single-cell profiling reveals distinct cardiac resident macrophages essential for zebrafish heart regeneration

The paper identifies distinct cardiac resident macrophage subpopulations critical for zebrafish heart regeneration through comparative single-cell profiling.

Genetic compensation is triggered by mutant mRNA degradation

The paper shows that mutant mRNA degradation triggers transcriptional adaptation in zebrafish and mouse, leading to upregulation of related genes.