Oncogenic mutations convert MET from a pro-apoptotic tumor suppressor to an oncogenic driver
Rémi Tellier, Marie Fernandes, Audrey Vinchent, Sonia Paget, Agathe Laratte, Céline Vuillier, Elisabeth Werkmeister, Céline Villenet, Jean‐Pascal Meneboo, Anne Chotteau‐Lelièvre, Eric Wasielewski, Zoulika Kherrouche, Marie‐José Truong, Clotilde Descarpentries, Luca Grumolato, , David Tulasne
The paper shows that MET exon 14 skipping mutations eliminate the pro-apoptotic function of MET, converting it from a tumor suppressor to an oncogenic driver in lung adenocarcinomas.
bioRxiv · Nov 10, 2025 · PreprintCancer Biology