Céline Villenet

Predicting Head and Neck Squamous Cell Carcinoma outcomes using long-term Patient-Derived Tumor Organoids

This study uses patient-derived tumor organoids to predict HNSCC patient outcomes, finding strong associations between organoid responses to cisplatin and X-rays and clinical prognosis.

Oncogenic mutations convert MET from a pro-apoptotic tumor suppressor to an oncogenic driver

The paper shows that MET exon 14 skipping mutations eliminate the pro-apoptotic function of MET, converting it from a tumor suppressor to an oncogenic driver in lung adenocarcinomas.

Long-term patient-derived ovarian cancer organoids closely recapitulate tumor of origin and clinical response

This study establishes patient-derived ovarian cancer organoids that mimic tumor characteristics and drug responses, showing potential for precision medicine.

Transcriptomic signatures of brain regional vulnerability to Parkinson’s disease

The paper identifies transcriptomic signatures of brain regional vulnerability to Parkinson’s disease by analyzing gene expression patterns across Braak Lewy body stages in human brain datasets.