Lei Gao

The paper describes the structure and function of a membrane-spanning E3 ubiquitin ligase complex, revealing its role in developmental processes and linking mutations to human birth defects.

This study identifies ATRN and ATRNL1 as transmembrane adapters that recruit MGRN1 to ubiquitinate and degrade MC1R and MC4R, expanding the known substrate repertoire of MGRN1.

The paper identifies diverse GABAergic neurons in the locus coeruleus (LC) dendritic field that modulate arousal and behaviors through transcriptional, spatial, and functional diversity.

The paper maps functional domains and subnetworks in the cortico-basal ganglia-thalamic loop in mice, revealing complex patterns of convergence and divergence.

The paper provides a detailed cellular-resolution map of the mouse primary motor cortex, defining cell types and their connectivity.

The paper creates a multiscale connectivity atlas of the mouse BLA by analyzing circuit-tracing data to identify distinct projection neuron domains and their brain-wide targets.

This study maps cortico-tectal projections in the mouse brain, identifying four collicular zones with distinct cortical inputs and subnetwork organization.