George Hedger

This study defines the mechanism of BSAP-1 toxin action, showing receptor recognition and protease-activation lead to pore formation in target cells.

The paper describes the structure and function of a membrane-spanning E3 ubiquitin ligase complex, revealing its role in developmental processes and linking mutations to human birth defects.

The paper uses molecular dynamics simulations and FRET assays to study lipid interactions with class B1 GPCRs, revealing state-dependent and conserved lipid binding patterns.

This study identifies an RNA-mediated DNA melting mechanism in CRISPR-Cas9 using simulations and experiments, showing RNA bases intercalate to promote strand separation.