Acyloxyacyl Hydrolase Modulates the Gut Microbiome Through Transcriptional Regulators of Corticotropin-Releasing Factor
Afrida Rahman-Enyart, Lizath Monserrath Aguiniga, Wen‐Bin Yang, Ryan E. Yaggie, Bryan A. White, Michael E. Welge, Loretta Sue Auvil, Matthew S. Berry, Colleen Bushell, Anthony J. Schaeffer, David J. Klumpp
This study shows that AOAH deficiency causes gut dysbiosis and pelvic pain, which can be mitigated by knocking out AhR and PPARγ in CRF-expressing cells, revealing a novel mechanism and therapeutic targets.
bioRxiv · Mar 4, 2021 · PreprintSystems Biology