Bryan A. White

This study shows AOAH deficiency causes gut dysbiosis and pelvic pain in mice, suggesting AOAH regulates microbiota and that microbiota may be a therapeutic target for IC/BPS.

This study shows that AOAH deficiency causes gut dysbiosis and pelvic pain, which can be mitigated by knocking out AhR and PPARγ in CRF-expressing cells, revealing a novel mechanism and therapeutic targets.