David J. Klumpp

MULTI-COHORT TRANSCRIPTOMIC ANALYSIS REVEALS SHARED INFLAMMATORY SIGNALING AND UROTHELIAL DYSFUNCTION ACROSS IC/BPS PHENOTYPES

This study identifies shared molecular signatures of inflammation and urothelial dysfunction across different IC/BPS phenotypes using multi-cohort transcriptomic analysis.

Microglial TLR4 Mediates Post-UTI Chronic Pelvic Pain

This study identifies microglial TLR4 as a critical mediator of post-UTI chronic pelvic pain in mice through functional and transcriptomic analyses.

Acyloxyacyl Hydrolase is a Host Determinant of Gut Microbiome-Mediated Pelvic Pain

This study shows AOAH deficiency causes gut dysbiosis and pelvic pain in mice, suggesting AOAH regulates microbiota and that microbiota may be a therapeutic target for IC/BPS.

Acyloxyacyl Hydrolase Modulates the Gut Microbiome Through Transcriptional Regulators of Corticotropin-Releasing Factor

This study shows that AOAH deficiency causes gut dysbiosis and pelvic pain, which can be mitigated by knocking out AhR and PPARγ in CRF-expressing cells, revealing a novel mechanism and therapeutic targets.

Acyloxyacyl Hydrolase Regulates Microglia-Mediated Pelvic Pain Through Toll-Like Receptor-4

This study shows AOAH and TLR4 regulate microglial activation and pelvic pain in IC/BPS by linking gut microbiota to CNS immune responses.