Author

John I. Clark

University of WashingtonORCID 0000-0002-6651-5205Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:Bayesian inference· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:phylogenetics / evolution· 1 Approach:statistical model· 1

Frequent Co-Authors

Alison F. FederiD· 1 shared Brendan F. KohrniD· 1 shared Charles C. ValentineiD· 1 shared Desiree A. MarshalliD· 1 shared Elizabeth K. SchmidtiD· 1 shared Eric Quentin KonnickiD· 1 shared Fang Yin LoiD· 1 shared Henry Marshall· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alison F. FederORCID

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintAug 20, 2026

✦ In-depth digest

Ultra-deep duplex sequencing reveals unique features of somatic evolution in the normal tissues of a family with Li-Fraumeni syndrome

Hunter Colegrove, Marianne E. Dubard-Gault, Henry Marshall…·Rosa Ana Risques

Duplex sequencing of a Li-Fraumeni family links germline TP53 p.R181H to higher neutral-region mutagenesis and weaker blood TP53 selection, plus recurrent p.R248Q/W hits across proband tissues.

DOI 10.64898/2026.01.12.699071

humanwhole-genome sequencing

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