Lauren E. Blake

This study compares gene expression variability and eQTLs in humans and chimpanzees, finding shared genetic and non-genetic determinants of inter-individual expression differences.

The paper compares gene expression and DNA methylation across tissues and species in primates, finding that only 7-11% of inter-species expression differences are explained by methylation, with higher explanation in tissue-specific genes.

This study uses Hi-C and RNA-seq to analyze 3D chromatin interactions and gene expression in human and chimpanzee iPSCs, finding that lower-order interactions are conserved while higher-order structures like TADs are not, and that inter-species differences in 3D structure correlate with gene expression differences.

This study compares endoderm differentiation in humans and chimpanzees using iPSCs, finding high conservation of gene regulatory trajectories despite species-specific expression differences.

The paper compares gene expression and regulatory differences between human and chimpanzee iPSC-derived cardiomyocytes and primary heart tissues to assess their utility for comparative genomic studies.