Author

Sofia Koletsi

Aligning Science Across Parkinson'sORCID 0000-0002-6661-7797Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:benchmarking· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Anthony H.V. SchapiraiD· 4 shared Kai‐Yin ChauiD· 3 shared Elisa MenozziiD· 2 shared Federico FierliiD· 2 shared Jane MacnaughtaniD· 2 shared Abigail HigginsiD· 1 shared Alexandre FamechoniD· 1 shared Aymeric DavidiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersNeuroscience

Anthony H.V. SchapiraORCID

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4 papers

Recent·Most cited

NeuroscienceFrontiers in NeurosciencePeer-reviewedOct 1, 2025

Exploring the relationship between GBA1 host genotype and gut microbiome in the GBA1L444P/WT mouse model: Implications for Parkinson disease pathogenesis

Elisa Menozzi, Mallia Geiger, Victoria Meslier…·Anthony H.V. Schapira

This study investigates whether GBA1 heterozygosity affects gut microbiome composition in a mouse model, finding no significant differences between genotypes.

3 citations

mousemetagenomics

NeuroscienceNeurobiology of DiseasePeer-reviewedAug 12, 2025

Reduction of a-synuclein aggregates by PIKfyve inhibition via TFEB-mediated lysosomal biogenesis in a Parkinson disease model

Sara Lucas Del Pozo, Giuseppe Uras, Federico Fierli…·Anthony H.V. Schapira

This study shows that PIKfyve inhibition reduces alpha-synuclein aggregates in a Parkinson's disease model by enhancing lysosomal biogenesis through TFEB activation.

7 citations

humanexperimental assay

NeuroscienceBrain CommunicationsPeer-reviewedJan 1, 2023

α-synuclein expression in response to bacterial ligands and metabolites in gut enteroendocrine cells

Michael J. Hurley, Elisa Menozzi, Sofia Koletsi…·Anthony H.V. Schapira

This study shows bacterial ligands and metabolites increase α-synuclein levels in gut enteroendocrine cells, potentially contributing to Parkinson's disease pathology.

22 citations

mousebulk RNA-seq

Genetic & Genomic MedicineCommunications BiologyPeer-reviewedJul 6, 2022

Comprehensive analysis of GBA using a novel algorithm for Illumina whole-genome sequence data or targeted Nanopore sequencing

Marco Toffoli, Xiao Chen, Fritz Joachim Sedlazeck…·Christos Proukakis

The paper presents two methods to accurately detect GBA variants and reciprocal recombinants, showing higher GBA variant frequency in Lewy body dementia compared to Parkinson's disease.

60 citationstop 2%

humanwhole-genome sequencing