Author

Kai‐Yin Chau

Aligning Science Across Parkinson'sORCID 0000-0002-5797-2922Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Anthony H.V. SchapiraiD· 4 shared Sofia KoletsiiD· 3 shared Elisa MenozziiD· 2 shared Federico FierliiD· 2 shared Jane MacnaughtaniD· 2 shared Matthew E. GeggiD· 2 shared Alexandre FamechoniD· 1 shared Aymeric DavidiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersNeuroscience

Anthony H.V. SchapiraORCID

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4 papers

Recent·Most cited

NeuroscienceFrontiers in NeurosciencePeer-reviewedOct 1, 2025

Exploring the relationship between GBA1 host genotype and gut microbiome in the GBA1L444P/WT mouse model: Implications for Parkinson disease pathogenesis

Elisa Menozzi, Mallia Geiger, Victoria Meslier…·Anthony H.V. Schapira

This study investigates whether GBA1 heterozygosity affects gut microbiome composition in a mouse model, finding no significant differences between genotypes.

3 citations

mousemetagenomics

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NeuroscienceNeurobiology of DiseasePeer-reviewedAug 12, 2025

Reduction of a-synuclein aggregates by PIKfyve inhibition via TFEB-mediated lysosomal biogenesis in a Parkinson disease model

Sara Lucas Del Pozo, Giuseppe Uras, Federico Fierli…·Anthony H.V. Schapira

This study shows that PIKfyve inhibition reduces alpha-synuclein aggregates in a Parkinson's disease model by enhancing lysosomal biogenesis through TFEB activation.

7 citations

humanexperimental assay

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NeuroscienceBrain CommunicationsPeer-reviewedJan 1, 2023

α-synuclein expression in response to bacterial ligands and metabolites in gut enteroendocrine cells

Michael J. Hurley, Elisa Menozzi, Sofia Koletsi…·Anthony H.V. Schapira

This study shows bacterial ligands and metabolites increase α-synuclein levels in gut enteroendocrine cells, potentially contributing to Parkinson's disease pathology.

22 citations

mousebulk RNA-seq

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GeneticsHuman Molecular GeneticsPeer-reviewedSep 18, 2022

The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines.

Laura J Smith, Magdalena M. Bolsinger, Kai‐Yin Chau…·Anthony H.V. Schapira

This study shows that the GBA E326K variant increases alpha-synuclein aggregation and lipid droplet accumulation in human cells without reducing GCase activity.

13 citations

humanproteomics

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