Author

Choushi Wang

Broad InstituteORCID 0000-0002-6667-1689Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Catherine Yijia Zhang· 1 shared Isaac Yi KimiD· 1 shared Longjun Li· 1 shared Melanie Fraidenburg· 1 shared Ping MuiD· 1 shared Siyuan ChengiD· 1 shared Xiao JiniD· 1 shared Yuyin JiangiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperCancer Biology

Catherine Yijia Zhang

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1 paper

Recent·Most cited

Graded Notch Signaling Functions as a Rheostat of Lineage Plasticity and Therapy Resistance in Prostate Cancer

Yuyin Jiang, Siyuan Cheng, Catherine Yijia Zhang, Xiao Jin, Longjun Li, Melanie Fraidenburg, Choushi Wang, Isaac Yi Kim, Ping Mu

This study identifies Notch signaling as a graded rheostat regulating lineage plasticity and therapy resistance in prostate cancer, showing that intermediate Notch activity maintains stem-like progenitor states and that modulating Notch levels can restore drug sensitivity.

bioRxiv · Nov 23, 2025 · PreprintCancer Biology