The paper examines transcriptomic changes in the spleen of three-spined stickleback populations with varying mercury levels, identifying differentially expressed genes linked to neurological, immunological, and splicing processes.

bioRxiv · Apr 29, 2024 · PreprintEcology

Whole genome and RNA sequencing of 1,220 cancers reveals hundreds of genes deregulated by rearrangement of cis-regulatory elements

Yiqun Zhang, Fengju Chen, Nuno A. Fonseca, Yao He, Masashi Fujita, Hidewaki Nakagawa, Zemin Zhang, Alvis Brāzma, PCAWG Transcriptome Working Group, Samirkumar B. Amin, Philip Awadalla, Peter J. Bailey, Alvis Brazma, Angela Norie Brooks, Claudia Calabrese, , Paul Alan Edwards

The paper identifies hundreds of genes deregulated by SVs in cancer, showing increased expression linked to SV breakpoints and enhancer elements.

Nature Communications · Feb 5, 2020Peer-reviewedGenomics

Genomic and Environmental Contributions to Chronic Diseases in Urban Populations

Marie-Julie Favé, Fabien Claude Lamaze, David M. Soave, Alan Hodgkinson, Héloïse Gauvin, Vanessa Bruat, Jean‐Christophe Grenier, Elias Gbeha, Kimberly Skead, Audrey Smargiassi, Markey Johnson, Youssef Idaghdour, Philip Awadalla

The paper investigates how environmental factors, particularly air pollution, interact with genetic variation to influence gene expression and chronic disease traits in an urban population.

Nature Communications · Feb 20, 2018Peer-reviewedGenomics