This study identifies 118 new genetic loci associated with Alzheimer's disease across diverse ancestries and discovers 48 novel risk loci, including those enriched in neuronal cell types.

medRxiv · Oct 10, 2025 · PreprintGenetic & Genomic Medicine

Network Signatures of Disease Progression and Core Symptoms in Dementia with Lewy Bodies Distinct from Alzheimer's Disease

Vincent Gabriel, Eléna Chabran, Marion Sourty, Benjamin Cretin, Nathalie Philippi, Candice Muller, Pierre Anthony, Catherine Demuynck, Paulo Loureiro de Sousa, Anne Botzung, Léa Sanna, Olivier Bousiges, Frédéric Blanc

The paper compares functional connectivity patterns in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), finding distinct network impairments linked to disease progression and symptoms.

bioRxiv · Jul 17, 2025 · PreprintNeuroscience

Identification of a sex-specific genetic signature in dementia with Lewy bodies: a meta-analysis of genome-wide association studies

Elizabeth Gibbons, Arvid Rongve, Itziar de Rojas, Alexey A. Shadrin, Kaitlyn Westra, Allison Baumgartner, Levi Rosendall, Zachary Madaj, Dena G. Hernandez, Owen A. Ross, Valentina Escott‐Price, Claire E. Shepherd, Laura Parkkinen, Sonja W. Scholz, Juan Carlos Troncoso, , Minna Oinas

This paper performs a large meta-analysis of GWAS in dementia with Lewy bodies, identifying sex-specific genetic risk signals and highlighting the need for larger cohorts.

medRxiv · Nov 22, 2022 · PreprintGenetic & Genomic Medicine