Byron Creese

This study identifies two epigenomic subtypes of late-onset Alzheimer's disease with distinct microglial and neuronal methylation signatures, linking them to different inflammatory and functional pathways.

This study identifies 118 new genetic loci associated with Alzheimer's disease across diverse ancestries and discovers 48 novel risk loci, including those enriched in neuronal cell types.

The paper identifies a DNA methylation module in the substantia nigra associated with depressive symptoms in Parkinson's disease.

This study investigates the genetic relationship between depression symptoms and Alzheimer's disease using GWAS and finds significant genetic correlations but no causal link, suggesting proxy cases may drive the overlap.

This paper performs a large meta-analysis of GWAS in dementia with Lewy bodies, identifying sex-specific genetic risk signals and highlighting the need for larger cohorts.

The paper identifies cardiovascular and infectious disease mechanisms linked to atypical antipsychotic side-effects using transcriptome analysis and bioinformatics.

This study finds a genetic link between schizophrenia polygenic risk and psychotic symptoms, particularly delusions, in Alzheimer's disease through a meta-analysis of 11 cohort studies.

The paper identifies 19 compounds from the CMAP library that show significant inverse correlation with Alzheimer's disease transcriptome signatures and pass in vitro screening assays.