The Proline-rich Domain Promotes Tau Liquid Liquid Phase Separation in Cells
Xuemei Zhang, Michael P. Vigers, James McCarty, Jennifer N. Rauch, Glenn H. Fredrickson, Maxwell Z. Wilson, Joan‐Emma Shea, Songi Han, Kenneth S. Kosik
The paper identifies the proline-rich domain (PRD) of tau as a driver of liquid-liquid phase separation (LLPS) in cells, showing its phosphorylation-dependent behavior and interaction with microtubules.
The Journal of Cell Biology · Aug 27, 2020Peer-reviewedNeuroscience