James McCarty

Undergraduate Biophysical Chemistry Series: Teaching through a Combination of a Purpose-built Textbook, Research-derived Biomolecular Samples and Computer Labs

The paper describes an integrative biophysics course combining a textbook, experimental samples, and computer labs to teach computational structural biology and spectroscopy.

An interaction between the transmembrane domains of Streptococcus pyogenes sortase A and its endogenous substrate M protein revealed by molecular dynamics simulations

The paper uses molecular dynamics simulations to model the interaction between Streptococcus pyogenes sortase A and its substrate M protein, revealing stereochemical features and potential transmembrane domain interactions that may enhance catalytic efficiency.

Biochemical characterization of Bacillus anthracis sortase B: Use in sortase mediated ligation and substrate recognition dependent on residues beyond the canonical pentapeptide binding motif for sortase enzymes

This study characterizes Bacillus anthracis SrtB, showing that residues outside the canonical pentapeptide motif are critical for activity and that engineered variants can improve ligation efficiency.

The Proline-rich Domain Promotes Tau Liquid Liquid Phase Separation in Cells

The paper identifies the proline-rich domain (PRD) of tau as a driver of liquid-liquid phase separation (LLPS) in cells, showing its phosphorylation-dependent behavior and interaction with microtubules.