Author

Stephen G. Withers

University of British ColumbiaORCID 0000-0002-6722-5701Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:metagenomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Aleksander C. LazarskiiD· 1 shared Ana S. Luis· 1 shared Carmen R. CoriiD· 1 shared Chloe Y. ZhangiD· 1 shared Chunsheng JiniD· 1 shared Deepesh PanwariD· 1 shared Eric C. MartensiD· 1 shared Eva BrencheriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Aleksander C. LazarskiORCID

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2 papers

Recent·Most cited

Degradation of mucin O-glycans by a human gut symbiont requires a complex enzyme repertoire and promotes colonization

Sadie R. Schaus, Chunsheng Jin, Grete Raba, Gabriel Vasconcelos Pereira, Rajneesh K. Bains, Carmen R. Cori, María-José García-Bonete, Marcus Nilsson, Naba D. Salman, Nicholas A. Pudlo, Qinnan Yang, Jining Liu, Jan Holgersson, Stephen G. Withers, Rachel Hevey, , Ana S. Luis

This study identifies the enzymatic pathway used by Bacteroides thetaiotaomicron to degrade colonic mucin O-glycans and shows that multiple exo-acting enzymes are critical for gut colonization.

bioRxiv · Mar 26, 2026 · PreprintMicrobiology

Functional metagenomics reveals an alternative, broad-specificity pathway for metabolism of carbohydrates in human gut commensal bacteria

Seyed A. Nasseri, Aleksander C. Lazarski, Imke L. Lemmer, Chloe Y. Zhang, Eva Brencher, Hongming Chen, Lyann Sim, Deepesh Panwar, Leo Betschart, L.J. Worrall, Harry Brumer, Natalie C. J. Strynadka, Stephen G. Withers

The paper identifies a novel, broad-specificity glycosidase pathway in gut bacteria that operates via a non-Koshland mechanism, capable of hydrolyzing diverse substrates including thioglycosides and pharmaceuticals.

Nature · Jun 19, 2024Peer-reviewedBiochemistry