María-José García-Bonete

Degradation of mucin O-glycans by a human gut symbiont requires a complex enzyme repertoire and promotes colonization

This study identifies the enzymatic pathway used by Bacteroides thetaiotaomicron to degrade colonic mucin O-glycans and shows that multiple exo-acting enzymes are critical for gut colonization.

Degradation of the intestinal mucus layer by the ETEC protease EatA is species specific determined by the structure of the MUC2 mucin

The paper shows ETEC protease EatA degrades human MUC2 mucin specifically, enabling bacterial infection by disrupting the intestinal mucus layer.

Functional Group Composition: The Blueprint for Protein Interactions

The paper introduces a compositional model to predict protein interactions, showing that functional group composition can reliably predict survivin binding without relying on amino acid sequences.

Survivin in synergy with BAF/SWI complex binds bivalent chromatin regions and activates DNA damage response in CD4+ T cells

This study shows survivin interacts with BAF/SWI complex at bivalent chromatin regions to repress DNA repair in IFNγ-stimulated CD4+ T cells, promoting autoimmune profiles.

Deciphering Peptide-Protein Interactions via Composition-Based Prediction: A Case Study with Survivin/BIRC5

The paper predicts peptide-protein interactions using a composition-based model, showing that electrostatic and primary structure features are insufficient for accurate predictions.

Survivin prevents the Polycomb Repressor Complex 2 from methylating Histone 3 lysine 27

The paper shows survivin interacts with PRC2, preventing H3K27 methylation and gene silencing in CD4+T cells.