Author

Sheila Lutz

University of MinnesotaORCID 0000-0002-6729-4598Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:yeast· 5 Assay:DNA methylation· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Research Focus:differential expression· 1 Research Focus:fine-mapping· 1

Frequent Co-Authors

Frank Wolfgang AlbertiD· 5 shared Christian BrioniD· 2 shared Krisna Van DykeiD· 2 shared Chad L. MyersiD· 1 shared Gemechu Mekonnen· 1 shared Margaret KliebhaniD· 1 shared Matthew A Feraru· 1 shared Megan Lawler· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 14 mutual co-author links

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5 shared papersGenetics

Frank Wolfgang AlbertORCID

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5 papers

Recent·Most cited

High-resolution, genotype-free mapping of genetic variation with CRI-SPA-Map

Sheila Lutz, Megan Lawler, Samuel Amidon, Frank Wolfgang Albert

The paper introduces CRI-SPA-Map, a genetic mapping strategy in yeast that identifies causal genetic variants for phenotypic differences without genotyping.

Genome Research · May 1, 2026Peer-reviewedGenetics

Multiple causal DNA variants in a single gene affect gene expression in trans

Sheila Lutz, Krisna Van Dyke, Matthew A Feraru, Frank Wolfgang Albert

The paper identifies multiple causal DNA variants within a single gene that affect gene expression in trans in yeast, showing complexity in trans-acting variation.

Genetics · Nov 15, 2021Peer-reviewedGenetics

Trans-acting genetic variation affects the expression of adjacent genes

Krisna Van Dyke, Sheila Lutz, Gemechu Mekonnen, Chad L. Myers, Frank Wolfgang Albert

The paper shows trans-eQTLs in yeast can affect adjacent genes through horizontal mechanisms, not just vertical pathways, and this is linked to physical proximity and shared chromatin states.

Genetics · Feb 3, 2021Peer-reviewedGenetics

Simultaneous quantification of mRNA and protein in single cells reveals post-transcriptional effects of genetic variation

Christian Brion, Sheila Lutz, Frank Wolfgang Albert

A CRISPR-based dual reporter assay identifies DNA variants affecting mRNA or protein levels in trans in yeast.

eLife · Nov 16, 2020Peer-reviewedGenetics

DNA variants affecting the expression of numerous genes in trans have diverse mechanisms of action and evolutionary histories

Sheila Lutz, Christian Brion, Margaret Kliebhan, Frank Wolfgang Albert

The paper identifies three trans-acting variants in yeast that affect gene expression through diverse mechanisms and evolutionary patterns.

PLoS Genetics · Nov 18, 2019Peer-reviewedGenetics