Author

Gemechu Mekonnen

University of Minnesota

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3 Developmental Biology· 1 Neuroscience· 1

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Research Focus:gene regulatory network inference· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Organism:C. elegans· 2 Approach:experimental assay· 2 Organism:yeast· 2 Assay:DNA methylation· 1

Frequent Co-Authors

David GreensteiniD· 2 shared Frank Wolfgang AlbertiD· 2 shared Tatsuya TsukamotoiD· 2 shared Aaron D. GitleriD· 1 shared Adam BrineriD· 1 shared Beryl B. CummingsiD· 1 shared Björn OskarssoniD· 1 shared Bradley F. BoeveiD· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersDevelopmental Biology

David GreensteinORCID

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5 papers

Recent·Most cited

Variation in Ubiquitin System Genes Creates Substrate-Specific Effects on Proteasomal Protein Degradation

Mahlon A. Collins, Gemechu Mekonnen, Frank Wolfgang Albert

The paper identifies genetic variants affecting UPS activity in yeast by mapping loci influencing N-degron recognition and ubiquitination.

eLife · Oct 11, 2022Peer-reviewedGenetics

TDP-43 represses cryptic exon inclusion in FTD/ALS gene UNC13A

X. Rosa Ma, Mercedes Prudencio, Yuka Mitsuhashi Koike, Sarat C. Vatsavayai, Garam Kım, Fred Harbinski, Adam Briner, Caitlin M. Rodriguez, Caiwei Guo, Tetsuya Akiyama, Hermann Broder Schmidt, Beryl B. Cummings, David W. Wyatt, Katherine Kurylo, Georgiana Miller, , Aaron D. Gitler

This study shows that TDP-43 represses a cryptic exon in UNC13A, and genetic variants associated with FTD/ALS increase cryptic exon inclusion when TDP-43 is dysfunctional.

Nature · Feb 23, 2022Peer-reviewedNeuroscience

Trans-acting genetic variation affects the expression of adjacent genes

Krisna Van Dyke, Sheila Lutz, Gemechu Mekonnen, Chad L. Myers, Frank Wolfgang Albert

The paper shows trans-eQTLs in yeast can affect adjacent genes through horizontal mechanisms, not just vertical pathways, and this is linked to physical proximity and shared chromatin states.

Genetics · Feb 3, 2021Peer-reviewedGenetics

Decreased torsinA or LINC Complex Function Rescues a Laminopathy in Caenorhabditis elegans

Gabriela Huelgas‐Morales, Mark Sanders, Gemechu Mekonnen, Tatsuya Tsukamoto, David Greenstein

The paper shows that reducing torsinA homolog OOC-5 function rescues sterility and premature aging in C. elegans laminopathy mutants.

bioRxiv · Apr 22, 2020 · PreprintDevelopmental Biology

Insights into the involvement of spliceosomal mutations in myelodysplastic disorders from an analysis of SACY-1/DDX41 in Caenorhabditis elegans

Tatsuya Tsukamoto, Micah D. Gearhart, Seongseop Kim, Gemechu Mekonnen, Caroline A. Spike, David Greenstein

This study investigates the role of DDX41 mutations in myelodysplastic syndromes using C. elegans SACY-1, revealing antimorphic activity and transcriptome changes through splicing-dependent and -independent mechanisms.

Genetics · Feb 14, 2020Peer-reviewedGenetics