Christian Brion

Hepatic isomiR landscaping reveals new biological insights into metabolic dysfunction in steatotic liver disease

The paper analyzes isomiR expression in MASLD liver biopsies and identifies isomiRs associated with disease severity and fibrosis, proposing novel mRNA targets.

Dynamics of transcription elongation are finely tuned by dozens of regulatory factors

The paper quantifies how transcription elongation in yeast is regulated by multiple factors balancing Pol II activity and gene expression.

Simultaneous quantification of mRNA and protein in single cells reveals post-transcriptional effects of genetic variation

A CRISPR-based dual reporter assay identifies DNA variants affecting mRNA or protein levels in trans in yeast.

Pervasive phenotypic impact of a large non-recombining introgressed region in yeast

The paper investigates the phenotypic impact of a large non-recombining introgressed region in Lachancea kluyveri yeast, identifying loci affecting growth and gene expression.

DNA variants affecting the expression of numerous genes in trans have diverse mechanisms of action and evolutionary histories

The paper identifies three trans-acting variants in yeast that affect gene expression through diverse mechanisms and evolutionary patterns.

Variation Of The Meiotic Recombination Landscape And Properties Over A Broad Evolutionary Distance In Yeasts

The paper examines meiotic recombination differences between Saccharomyces cerevisiae and Lachancea kluyveri, finding significant variations in recombination rates, crossover patterns, and hotspot conservation across evolutionary distances.