The paper identifies the proteomic composition and functional interdependence of the vertebrate C2a projection, showing that loss of any of three proteins causes ciliary dysfunction and primary ciliary dyskinesia in mice.

bioRxiv · Jun 1, 2026Cell Biology

Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function.

Denis Dacheux, Guillaume Martinez, Christine E. Broster Reix, Julie Beurois, Patrick Lorès, Magamba Tounkara, Jean‐William Dupuy, Derrick Roy Robinson, Corinne Loeuillet, Emeline Lambert, Zeina Wehbe, Jessica Escoffier, Amir Amiri‐Yekta, Abbas Daneshipour, Seyedeh‐Hanieh Hosseini, , Charles Coutton

The paper identifies ZMYND12 as a gene associated with male infertility and flagellum function through genetic and functional studies in humans and Trypanosoma brucei.

eLife · Nov 7, 2023Peer-reviewedGenetics

Attenuating amyloid-beta pathology in mice with in situ programmed astrocytes

Lun Zhang, Shuai Lü, Yingbo Jia, Shengjie Hou, Jie Zhu, Xiaoge Liu, Xiaoying Sun, Yaru Huang, Yu-xuan Zhao, Hongan Ren, Chunyu Liu, Fang Cui, Dong‐qun Liu, Xiao-yu Du, Xiao-yun Niu, , Rui‐tian Liu

This study introduces CAR-engineered astrocytes to target Aβ oligomers in Alzheimer's disease, showing improved phagocytosis and reduced inflammation in mice.

bioRxiv · Oct 30, 2023 · PreprintNeuroscience