Hongbin Liu

The paper identifies the proteomic composition and functional interdependence of the vertebrate C2a projection, showing that loss of any of three proteins causes ciliary dysfunction and primary ciliary dyskinesia in mice.

This study uses human organoids to show that PTEN suppresses retinoic acid signaling to drive mesendoderm specification.

The paper assesses the clinical validity of 56 genes associated with lysosomal diseases using the ClinGen framework, identifying key themes and challenges in their evaluation.

This study shows that Tmc7 deficiency in mice causes acrosome biogenesis defects and male infertility by disrupting Golgi function and ion homeostasis.

This study shows LSM14B is essential for MARDO assembly in mouse oocytes, leading to meiotic maturation failure and infertility.

This study shows that SSH2 is essential for acrosome biogenesis and male fertility in mice by regulating actin remodeling through COFILIN.

This study identifies CFAP53 as essential for sperm flagellum biogenesis, showing its role in male infertility and interactions with proteins in the manchette and sperm tail.

This study identifies ZCWPW1 as an H3K4me3 reader required for DSB repair and synapsis in mouse testes, showing its dependency on PRDM9 activity.