Christophe Arnoult

Sperm motility restoration in mice suffering from oligo-astheno-teratozoospermia by in vivo injection and electroporation of naked mRNA

This study uses in vivo mRNA electroporation to restore sperm motility in ARMC2-deficient mice, demonstrating a potential treatment for male infertility.

ATAD2 mediates chromatin-bound histone chaperone turnover

This study shows ATAD2 regulates chromatin-bound histone chaperone turnover, affecting H3.3 localization and gene transcription during spermatogenesis.

Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function.

The paper identifies ZMYND12 as a gene associated with male infertility and flagellum function through genetic and functional studies in humans and Trypanosoma brucei.

Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse

This study identifies bi-allelic CCDC146 mutations as a cause of non-syndromic male infertility in humans and mice, showing its role in sperm flagellum structure and microtubule organization.

Oligogenic heterozygous inheritance of sperm abnormalities in mouse

The paper investigates oligogenic inheritance of sperm abnormalities in mice, finding that increasing numbers of heterozygous mutations worsen sperm morphology and motility.