Nucleolar-based Dux repression is essential for 2-cell stage exit
Sheila Q. Xie, Bryony J. Leeke, Chad Whilding, Ryan T. Wagner, Ferran Garcia-Llagostera, Yixuan Low, Paul Chammas, Nathan T.-F. Cheung, Dirk Dormann, Michael T. McManus, Michelle Percharde
This study shows that nucleolar maturation and rRNA synthesis are required to repress Dux and exit the 2-cell stage in embryos.
Genes & Development · Mar 1, 2022Peer-reviewedDevelopmental Biology