Michelle Percharde

The paper investigates the role of Dux and MERVL in ZGA, totipotency, and cell toxicity using CRISPRa and a 2C-GFP reporter system, finding that MERVL activation contributes to expanded fate potential but not all totipotency features, while Dux-induced toxicity is independent of MERVL and involves Noxa.

The paper identifies a lipid metabolism-induced checkpoint during the exit of naïve pluripotency that ensures genome integrity through telomere regulation.

The paper identifies a dual enhancer-silencer element at the Cdx2 locus that controls transient Cdx2 expression during posterior body formation in mice.

The paper identifies mechanisms that prevent innate immune activation by TE-derived cytosolic DNA, preserving pluripotency in ESCs.

This study shows that nucleolar maturation and rRNA synthesis are required to repress Dux and exit the 2-cell stage in embryos.

This study identifies L1 and B1 retrotransposons as key elements shaping the 3D chromatin structure through spatial compartmentalization in human and mouse cells.

The paper shows that translation directly regulates chromatin state and transcription in ES cells, with reduced translation causing rapid chromatin changes.