Inhibition of cytosolic DNA sensing and transposon activity safeguards pluripotency
Ferran Garcia-Llagostera, Audrey L. K. Putman, Alexandros Choromidis, Bryony J. Leeke, Klaudia Stanik, Antonia Ramos, Benjamin Moyon, Jesús Gil, Alexis R. Barr, Michelle Percharde
The paper identifies mechanisms that prevent innate immune activation by TE-derived cytosolic DNA, preserving pluripotency in ESCs.
bioRxiv · Mar 26, 2025 · PreprintDevelopmental Biology