ImmunologybioRxivPreprint
AID facilitates TET2 demethylation of Irf4 for plasma cell fate in germinal center B cells
Minghui He, Roberta D’Aulerio, Lia Gonçalves Pinho…·Lisa S. Westerberg
This study shows AID deficiency in B cells leads to reduced IRF4 expression and impaired plasma cell differentiation due to disrupted TET2-mediated demethylation of the Irf4 promoter.
DOI 10.1101/2025.05.02.651162