Lisa S. Westerberg

This study identifies parthenolide as a potential therapy for Wiskott-Aldrich syndrome by enhancing megakaryocyte maturation and platelet function in both cell and mouse models.

This paper systematically analyzes how patient variants affect WASp activity, identifying gain-of-function and loss-of-function variants through structural and functional assays.

This study identifies resistant subclones in pediatric lymphoma using scRNA-seq and scVDJ-seq, revealing progenitor-like cells and potential therapeutic targets like MSI2.

This study shows AID deficiency in B cells leads to reduced IRF4 expression and impaired plasma cell differentiation due to disrupted TET2-mediated demethylation of the Irf4 promoter.

This study shows that antigen affinity and immunization site influence B cell recall responses, with low affinity boosts leading to higher SHM but fewer memory B cells in secondary GCs.