Minghui He

Parthenolide boosts megakaryocyte maturation and restores platelet responses in Wiskott Aldrich syndrome

This study identifies parthenolide as a potential therapy for Wiskott-Aldrich syndrome by enhancing megakaryocyte maturation and platelet function in both cell and mouse models.

A systematic approach to understanding how patient variants affect the activity of Wiskott-Aldrich syndrome protein

This paper systematically analyzes how patient variants affect WASp activity, identifying gain-of-function and loss-of-function variants through structural and functional assays.

Single cell analysis reveals molecular traits of pediatric lymphoma resistant subclones

This study identifies resistant subclones in pediatric lymphoma using scRNA-seq and scVDJ-seq, revealing progenitor-like cells and potential therapeutic targets like MSI2.

AID facilitates TET2 demethylation of Irf4 for plasma cell fate in germinal center B cells

This study shows AID deficiency in B cells leads to reduced IRF4 expression and impaired plasma cell differentiation due to disrupted TET2-mediated demethylation of the Irf4 promoter.

N6-Methyladenine DNA Modification in Human Genome

This study identifies widespread N6-methyladenine (6mA) modification in the human genome, links it to gene expression, and shows its role in cancer by demonstrating reduced 6mA levels in tumors.