Ryan P.D. Alexander

This study investigates the distinct roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability using inhibitors and genetic modifications to selectively block each isoform.

This study investigates how delta opioid receptors modulate GABA release in prefrontal interneurons through distinct signaling pathways, affecting synaptic inhibition in somatic and dendritic compartments.

The paper shows that loss of NaV1.2 sodium channels in pyramidal neurons leads to hyperexcitability and seizures despite reduced action potential size and speed.