The specific AMPK activator A-769662 ameliorates pathological phenotypes following mitochondrial DNA depletion
Gustavo Carvalho, Bruno Marçal Repolês, Tran Nguyen, Josefin M. E. Forslund, Farahnaz Ranjbarian, Isabela Cecília Mendes, Micol Falabella, Mara Doimo, Sjoerd Wanrooij, Robert D. S. Pitceathly, Anders Hofer, Paulina H. Wanrooij
This study shows that the AMPK activator A-769662 improves mitochondrial function and partially restores mtDNA levels in cells with mtDNA depletion.
bioRxiv · Mar 14, 2024 · PreprintMolecular Biology