Josefin M. E. Forslund

This study investigates the endoribonuclease activity of hTop1mt and finds it less efficient than hTop1, explaining the tolerance of rNMPs in mtDNA.

The study shows the Y951N mutation in POLgamma impairs its ability to switch between DNA synthesis and degradation, causing mtDNA depletion without directly affecting polymerase or exonuclease activity.

This study shows that the AMPK activator A-769662 improves mitochondrial function and partially restores mtDNA levels in cells with mtDNA depletion.