Tran Nguyen

This study identifies redox-dependent dimerization of PolDIP2 and a conserved ApaG-domain motif critical for CHCHD2 interaction, revealing structural features governing its mitochondrial function.

The study shows the Y951N mutation in POLgamma impairs its ability to switch between DNA synthesis and degradation, causing mtDNA depletion without directly affecting polymerase or exonuclease activity.

This study shows that the AMPK activator A-769662 improves mitochondrial function and partially restores mtDNA levels in cells with mtDNA depletion.