NeuroscienceNeurobiology of DiseasePeer-reviewed
Cortistatin neurons in the prelimbic cortex regulate seizure susceptibility in female mice via BDNF-TrkB signaling
Aaron J. Salisbury, Lourdes Figueroa, Keri Martinowich, Michael S. Totty
This study shows that loss of cortistatin (CST) neurons in the prelimbic cortex increases seizure susceptibility and anxiety-like behaviors in female mice, suggesting shared mechanisms between epilepsy and stress-related disorders.
DOI 10.1016/j.nbd.2026.107498