Keri Martinowich

Overlapping yet distinct spatiomolecular profiles across mood disorders and biological sex in the human prefrontal cortex

The paper uses spatial transcriptomics to analyze molecular differences in mood disorders and biological sex in the human prefrontal cortex, identifying sex- and disorder-specific gene expression patterns.

Three dimensional reconstruction of the human nucleus accumbens reveals topographic organization and molecular heterogeneity of D1-islands across the anterior posterior axis

This paper develops a 3D spatial genomics framework to reconstruct the molecular and cellular organization of the human nucleus accumbens across anatomical axes.

Pathogenic tau in the mouse locus coeruleus induces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimers disease

This study shows that pathogenic tau in the locus coeruleus causes hyperactivity and neuropsychiatric symptoms similar to early Alzheimer's disease in mice.

Multiscale spatial transcriptomics resolves the cellular and molecular architecture of the human amygdala

This study creates a spatial transcriptomic atlas of the human amygdala, revealing distinct cell types and genetic risk localization across its subnuclei.

Molecular impact of nicotine and smoking exposure on the developing and adult mouse brain

This study compares the molecular effects of prenatal nicotine exposure and maternal smoking during pregnancy on mouse brain development and adulthood, finding distinct gene expression changes in pups but not adults.

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens

This study creates a spatiomolecular atlas of the human nucleus accumbens using spatial transcriptomics and single-nucleus RNA sequencing, revealing spatial gradients and conserved features across species.

Cortistatin neurons in the prelimbic cortex regulate seizure susceptibility in female mice via BDNF-TrkB signaling

This study shows that loss of cortistatin (CST) neurons in the prelimbic cortex increases seizure susceptibility and anxiety-like behaviors in female mice, suggesting shared mechanisms between epilepsy and stress-related disorders.

Perturbation of genes linked to common schizophrenia risk variants identifies cilia programs

The paper perturbs schizophrenia risk genes in mice to identify ciliary transcriptional programs as a potential downstream mechanism of disease.

Spatio-molecular gene expression reflects dorsal anterior cingulate cortex structure and function in the human brain

The paper integrates spatial transcriptomics and single-nucleus RNA-seq data from the human dACC to define molecular profiles, spatial domains, and functional insights.

Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex

This study maps molecular and genetic signatures of schizophrenia in human prefrontal cortex across spatial scales, revealing altered BDNF-TrkB signaling and inhibitory circuit dysfunction.

Spatially-resolved molecular sex differences at single cell resolution in the adult human ventromedial and arcuate hypothalamus

The paper creates a single-cell atlas of sex-differentially expressed genes in human hypothalamus regions, revealing molecular sex differences and their links to neurodevelopmental disorders.

spaTransfer: transfer learning for single-cell and spatial transcriptomics data using non-negative matrix factorization

spaTransfer transfers cell type or spatial domain labels between single-cell and spatial transcriptomics datasets using non-negative matrix factorization and a multinomial model.

Top-down control of sustained attention by the medial prefrontal cortex (mPFC)- locus coeruleus (LC) circuit during the rodent continuous performance task (rCPT)

This study investigates the role of the mPFC-LC circuit in sustained attention using chemogenetic manipulation in mice, finding that selective activation of mPFC-LC projectors improves attentional performance through distinct neural mechanisms.

Orchestrating Spatial Transcriptomics Analysis with Bioconductor

The paper provides an open-source online book for analyzing spatial transcriptomics data using Bioconductor in R, with reproducible code and datasets.

APOE E4 Alzheimer's Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex

The paper investigates how APOE genotype affects gene expression in the human entorhinal cortex, identifying an oligodendrocyte subtype as a potential mediator of Alzheimer's disease risk.

Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test

The paper examines how neural activity in the prelimbic cortex correlates with attentional behavior in mice during the rodent continuous performance test.

Impact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus

The paper analyzes the transcriptomic landscape of the human locus coeruleus in relation to Alzheimer's disease risk factors and neuromelanin content using spatially-resolved transcriptomics.

Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates

The paper analyzes transcriptomic diversity in amygdalar subdivisions across humans and nonhuman primates using single-nucleus RNA sequencing and identifies distinct neuronal subtypes and transcriptional specializations.

An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus

The paper integrates single-nucleus and spatial transcriptomics data to map the molecular landscape of the human hippocampus, identifying cell types and spatial domains.

Spatial domain detection using contrastive self-supervised learning for spatial multi-omics technologies

Proust detects spatial domains using contrastive self-supervised learning on multi-omics data, showing improved accuracy across benchmark datasets.

Time-on-task-related decrements in performance in the rodent continuous performance test are not caused by physical disengagement from the task

This study shows that performance decline in the rodent Continuous Performance Test (rCPT) over time is due to vigilance decrements, not physical disengagement, and amphetamine improves performance without affecting task engagement.

Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation

This study analyzes age-related changes in gene expression in the human dentate gyrus, identifying shifts in neurogenesis, maturation, and neuroinflammation across the lifespan.

Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species

The paper performs snRNA-seq on human lateral septum tissue to identify cell types and marker genes, finding conserved and species-specific expression patterns.

Integrating gene expression and imaging data across Visium capture areas with visiumStitched

The paper introduces visiumStitched, a tool for stitching Visium spatial transcriptomics data across multiple capture areas, enabling seamless analysis without data loss.

Stimulation of locus coeruleus inputs to the frontal cortex in mice induces cell type-specific expression of the Apoe gene

The paper stimulates locus coeruleus inputs to the frontal cortex in mice and finds cell type-specific Apoe gene expression, particularly in GABAergic neurons, with sex-dependent effects.

Reelin marks cocaine-activated striatal ensembles, promotes neuronal excitability, and regulates cocaine reward

This study identifies Reelin as a marker of cocaine-activated neuronal ensembles in the rat nucleus accumbens and shows its role in cocaine reward and neuronal excitability.

Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex

The paper generates a molecular neuroanatomical map of the human prefrontal cortex using spatial transcriptomics and single nucleus RNA-sequencing, revealing novel spatial domains and cell-cell interactions linked to psychiatric disorders.

Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons

This study investigates the functional roles of Bdnf I and Bdnf IV transcript variants in hippocampal neurons using CRISPRa, finding distinct effects on dendritic growth and fear behavior.

TrkB-dependent regulation of molecular signaling across septal cell types

This study investigates TrkB signaling in the lateral septum using RNA-seq, identifying gene expression changes linked to psychiatric and neurodegenerative disorders.

Influence of Alzheimer's disease related neuropathology on local microenvironment gene expression in the human inferior temporal cortex

The paper uses spatial proteogenomics to analyze gene expression changes in Alzheimer's disease brains linked to amyloid-beta and tau pathology.