Bernard Mulvey

The paper uses spatial transcriptomics to analyze molecular differences in mood disorders and biological sex in the human prefrontal cortex, identifying sex- and disorder-specific gene expression patterns.

This study shows that pathogenic tau in the locus coeruleus causes hyperactivity and neuropsychiatric symptoms similar to early Alzheimer's disease in mice.

The paper creates a single-cell atlas of sex-differentially expressed genes in human hypothalamus regions, revealing molecular sex differences and their links to neurodevelopmental disorders.

The paper investigates how APOE genotype affects gene expression in the human entorhinal cortex, identifying an oligodendrocyte subtype as a potential mediator of Alzheimer's disease risk.

The paper analyzes the transcriptomic landscape of the human locus coeruleus in relation to Alzheimer's disease risk factors and neuromelanin content using spatially-resolved transcriptomics.

The paper examines sex biases in gene expression across brain regions and links them to sex differences in autism and Alzheimer's disease prevalence.

This study shows that tyrosinase-induced neuromelanin accumulation in mouse locus coeruleus neurons causes hyperactivity, transcriptional changes, and degeneration, mimicking early stages of Alzheimer's and Parkinson's disease.

This study uses DSP-4 to model early LC-NE system changes in AD and PD, showing axon damage, neuroinflammation, and behavioral changes without LC cell death.

The paper profiles hippocampal transcriptomes across estrous cycles in mice, identifies estrous-responsive genes, and shows Cnih3 deletion disrupts estrous-specific gene expression patterns.

The paper identifies sex-dependent functional variants in depression risk loci using in vivo assays, showing sex-by-allele effects in hippocampal neurons.

The paper identifies functional MDD risk variants using MPRAs and shows their convergence on retinoid receptor TFs and serotonergic neuron-specific motifs.

The paper identifies BNST-PBN neural circuits that modulate feeding by integrating threat assessment and feeding drive.

The paper reviews Massively Parallel Reporter Assays (MPRAs) as a tool for identifying functional psychiatric genetic variants and discusses their potential applications in neurogenetics.