Michael S. Totty

This study creates a spatial transcriptomic atlas of the human amygdala, revealing distinct cell types and genetic risk localization across its subnuclei.

This study identifies transcriptomic changes in rat habenula and amygdala after chronic fentanyl self-administration, linking them to human cell types and risk genes for addiction.

This study shows that loss of cortistatin (CST) neurons in the prelimbic cortex increases seizure susceptibility and anxiety-like behaviors in female mice, suggesting shared mechanisms between epilepsy and stress-related disorders.

The paper integrates spatial transcriptomics and single-nucleus RNA-seq data from the human dACC to define molecular profiles, spatial domains, and functional insights.

SpatialArtifacts identifies and classifies tissue artifacts in spatial transcriptomics data using MAD-based outlier detection and mathematical morphology operations.

The paper identifies a circuit involving DLS Pdyn neurons that links contextual cues to feeding regulation through inhibition of LHA GABAergic neurons.

SpotSweeper-py provides spatially-aware quality control metrics for spatial omics data in Python, improving accuracy by reducing false positives and preserving tissue-specific architecture.

The paper investigates hippocampal-prelimbic coupling during context-dependent extinction retrieval in rats and finds increased theta oscillation coherence and directional coupling between the dorsal hippocampus and prelimbic cortex.

The paper provides an open-source online book for analyzing spatial transcriptomics data using Bioconductor in R, with reproducible code and datasets.

The paper examines how neural activity in the prelimbic cortex correlates with attentional behavior in mice during the rodent continuous performance test.

The paper analyzes transcriptomic diversity in amygdalar subdivisions across humans and nonhuman primates using single-nucleus RNA sequencing and identifies distinct neuronal subtypes and transcriptional specializations.

This study investigates the role of the nucleus reuniens in fear conditioning and extinction in rodents and humans, finding that RE activity reflects associative value and defensive behavior.

SpotSweeper improves spatial transcriptomics QC by identifying local outliers and regional artifacts, enhancing downstream analysis.

This study investigates how transplanted neural progenitor cell-derived neurons integrate into spinal cord locomotor circuits and their functional impact on motor recovery after injury.

This study shows that the thalamic nucleus reuniens coordinates prefrontal-hippocampal theta oscillations to suppress extinguished fear in rats.

This study shows that BLA neurons encode both recent and remote fear memories, indicating the BLA stores emotional memories long-term.

This study investigates context-dependent flight behavior in rats, showing that contextual fear influences flight responses and that amygdala inactivation reduces both contextual and flight behaviors.