The paper identifies an age-associated immune-poised state in human bronchial epithelial cells that mediates RSV resistance in adults by enhancing RIG-I-STAT3 signaling.

Nature Communications · Jul 21, 2026Peer-reviewedMicrobiology

Lrp1 facilitates infection of neurons by Jamestown Canyon virus

Zachary D. Frey, David A. Price, Kaleigh A. Connors, Rachael E. Rush, G. Schuyler Brown, Cade E. Sterling, Farheen Fatma, Madeline M. Schwarz, Safder S. Ganaie, Xiaoxia Cui, Zachary P. Wills, Daisy W. Leung, Gaya K. Amarasinghe, Amy L. Hartman

This study identifies Lrp1 as a host factor required for Jamestown Canyon virus infection of neurons and shows it is shared by other bunyaviruses.

Journal of Virology · Nov 28, 2025Peer-reviewedMicrobiology

Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling

Grace Uwase, Priya Luthra, Olivia A. Vogel, Jyoti Batra, Bruno La Rosa, Kathleen C. F. Sheehan, Oam U. Khatavkar, Jacqueline E. Payton, Robert A. Davey, Nevan J. Krogan, Christopher F. Basler, Daisy W. Leung, Gaya K. Amarasinghe

This study identifies and characterizes the NNLNS motif in Ebola virus VP35 that mediates MIB2 binding, inhibiting IFN production and affecting viral RNA synthesis.

Proceedings of the National Academy of Sciences · Sep 22, 2025Peer-reviewedMicrobiology

Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics

Rebecca J. Carlson, J. J. Patten, George Stefanakis, Brian Y. Soong, Adityanarayanan Radhakrishnan, Avtar K Singh, Naveen Thakur, Kathleen C. F. Sheehan, Gaya K. Amarasinghe, Nir Hacohen, Christopher F. Basler, Daisy W. Leung, Caroline Uhler, Robert A. Davey, Paul C. Blainey

This study uses single-cell image-based CRISPR screens to identify host factors regulating Ebola virus infection, revealing new therapeutic targets like UQCRB and STRAP.

Nature Microbiology · Jul 24, 2025Peer-reviewedMicrobiology

Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple AD ligands

Jessica A. Greven, Joshua R. Wydra, Rory A. Greer, Cynthia Zhi, David A. Price, Jordyn D. Svoboda, Christopher Camitta, Mya Washington, Daisy W. Leung, Yuhua Song, Jennifer M Alexander‐Brett, Tom J. Brett

This study maps TREM2-ligand interactions using biolayer interferometry, revealing shared binding surfaces for apoE4, oAb42, and TDP-43, and a unique site for IL-34.

Molecular Neurodegeneration · Jan 9, 2025Peer-reviewedBiophysics

Peptide-antibody Fusions Engineered by Phage Display Exhibit Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants

Jonathan M. Labriola, Shane Miersch, Gang Chen, Chao Chen, Alevtina Pavlenco, Reza Saberianfar, Francesca Caccuri, Alberto Zani, Nitin Sharma, Annie Feng, Daisy W. Leung, Arnaldo Caruso, Giuseppe Novelli, Gaya K. Amarasinghe, Sachdev S. Sidhu

This paper describes the engineering of peptide-antibody fusions using phage display to enhance neutralization potency and breadth against SARS-CoV-2 variants.

ACS Chemical Biology · Jun 22, 2022Peer-reviewedSynthetic Biology

Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations

Shane Miersch, Zhijie Li, Reza Saberianfar, Mart Ustav, James Brett Case, Levi L. Blazer, Chao Chen, Wei Ye, Alevtina Pavlenco, Maryna Gorelik, Julia Garcia Perez, Suryasree Subramania, Serena Singh, Lynda Ploder, Safder S. Ganaie, , Sachdev S. Sidhu

This paper develops tetravalent SARS-CoV-2 neutralizing antibodies that are more potent and resistant to escape mutations than bivalent versions.

Journal of Molecular Biology · Jul 28, 2021Peer-reviewedSynthetic Biology