Cancer BiologybioRxivPreprint
Cell cycle control of chromatin creates a therapeutic window for epigenetic therapy in tumors
Kourosh Hayatigolkhatmi, Riccardo Valzelli, Elena Ceccacci…·Saverio Minucci
This paper shows that extending G1 phase in cancer cells creates a therapeutic window for epigenetic drugs, with LSD1 inhibition and CDK4/6 inhibition working synergistically to induce differentiation and improve survival in AML models.