Elena Ceccacci

Cell cycle control of chromatin creates a therapeutic window for epigenetic therapy in tumors

This paper shows that extending G1 phase in cancer cells creates a therapeutic window for epigenetic drugs, with LSD1 inhibition and CDK4/6 inhibition working synergistically to induce differentiation and improve survival in AML models.

LSD1 serine 166 is a phosphorylation switch for chromatinlandscaping, gene activation, and tissue remodeling

This paper identifies S166 phosphorylation on LSD1 as a regulatory switch that controls gene activation, chromatin remodeling, and tumor microenvironment in non-hormonal cancer cells.

A refined single cell landscape of haematopoiesis in the mouse foetal liver

The paper generates a refined single-cell landscape of haematopoiesis in the mouse foetal liver using scRNA-seq, identifying new cell populations and transcriptional dynamics.

KIT is required for fetal liver erythropoiesis but dispensable for angiogenesis

The paper shows KIT is required for fetal liver erythropoiesis but not for yolk sac endoHT or brain angiogenesis.