Saverio Minucci

This paper shows that extending G1 phase in cancer cells creates a therapeutic window for epigenetic drugs, with LSD1 inhibition and CDK4/6 inhibition working synergistically to induce differentiation and improve survival in AML models.

This paper develops a dual-reporter mouse system to analyze NF-kB and STAT6 signaling dynamics during mRNA vaccination, revealing liver as a key early hub and linking early STAT6 activation to robust humoral responses.

This paper identifies S166 phosphorylation on LSD1 as a regulatory switch that controls gene activation, chromatin remodeling, and tumor microenvironment in non-hormonal cancer cells.

This paper introduces an automated method for analyzing the cell cycle in both adherent and non-adherent cells using machine learning, validated in AML cell lines and drug response testing.

The paper generates a refined single-cell landscape of haematopoiesis in the mouse foetal liver using scRNA-seq, identifying new cell populations and transcriptional dynamics.