Antonello Mai

This paper shows that extending G1 phase in cancer cells creates a therapeutic window for epigenetic drugs, with LSD1 inhibition and CDK4/6 inhibition working synergistically to induce differentiation and improve survival in AML models.

This study examines how SAHA affects skeletal muscle differentiation in C2C12 and L6 cells, showing delayed early differentiation and model-dependent changes in gene and protein expression.

This study investigates how Remodelin, a Nat10 inhibitor, affects myoblast differentiation in murine and rat cells, showing impaired myotube formation and maturation.

This study identifies quinoline-based compounds that inhibit DNA methyltransferases and other DNA-targeting enzymes, with compound 11 inducing DNA damage response in cancer cells.

This study shows that inhibiting SmLSD1 with MC3935 causes transcriptional changes and structural damage in Schistosoma mansoni, leading to parasite death.